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Mediators of Inflammation
Volume 2008, Article ID 496467, 5 pages
Research Article

Citrus/Cydonia Comp. Can Restore the Immunological Balance in Seasonal Allergic Rhinitis-Related Immunological Parameters In Vitro

1Department of Healthcare and Nutrition, Louis Bolk Instituut, 3972 LA Driebergen, The Netherlands
2Department of Care, University of Applied Sciences Leiden, 2333 CK Leiden, The Netherlands
3Department of Cell Biology and Immunology, Wageningen University, 6700 AH Wageningen, The Netherlands

Received 30 July 2008; Accepted 5 November 2008

Academic Editor: Magdalena Klink

Copyright © 2008 E. W. Baars and H. F. J. Savelkoul. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In two in vitro studies, we examined the immunological (pathways of the) effects of Citrus/Cydonia comp. from, respectively, a healthy and an allergic donor; peripheral blood mononuclear cells (PBMCs) were isolated out of peripheral blood and analyzed in vitro after polyclonal stimulation of T-cells. The differentiation capacity and the influence with regard to Th1 (IFN- ) and Th2 (IL-5) cells were examined. Citrus/Cydonia comp. has a selective effect on the differentiation of T-cells by producing relatively more IL-10 than IL-12. By that, it also seems to have an effect on the induction of regulatory (IL-10 producing) T-cell subsets. It is in vitro capable of neutralizing (to some extent) the changes, characteristic to allergic rhinitis, with regard to the maturation, differentiation, and activity of the immune system. Thus, Citrus/Cydonia comp. can potentially restore the disturbed immune state of rhinitis patients, which essentially could be sufficient to make allergic symptoms disappear permanently.