Toll-Like Receptors and Cytokines as Surrogate Biomarkers for Evaluating Vaginal Immune Response following Microbicide Administration

<table>Determination of total and phosphorylated NF-<i>k</i>B p65 protein levels by ELISA as per the protocol described in materials and methods. No change was observed in total NF-<i>k</i>B levels. However, the phosphorylated NF-<i>k</i>B protein levels were significantly elevated in SDS gel administered animals.</table>

Mediators of Inflammation

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Figure 10

Figure 10: Toll-Like Receptors and Cytokines as Surrogate Biomarkers for Evaluating Vaginal Immune Response following Microbicide Administration 