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Mediators of Inflammation
Volume 2008, Article ID 619704, 7 pages
Research Article

Proinflammation and Hypertension: A Population-Based Study

1Unit of Family Practice, Central Hospital of Middle Finland, 40620 Jyväskylä, Finland
2Department of Family Medicine, School of Public Health and Clinical Nutrition, Unit of Family Practice, Kuopio University Hospital, Kuopio University, 70211 Kuopio, Finland
3Department of Rheumatology, Rheumatism Foundation Hospital, 18120 Heinola, Finland

Received 21 April 2008; Revised 3 October 2008; Accepted 8 November 2008

Academic Editor: Charles Larry Campbell

Copyright © 2008 Mauno Vanhala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


There is evidence that proinflammation may be linked to the development of hypertension (HT). We examined the association of both the interleukin-1 beta (IL-1 ) and the interleukin 1-receptor antagonist (IL-1ra) with future blood pressure (BP) and HT occurrence (  mmHg, or antihypertensive drug) in a population-based prospective study. Our study consisted of 396 (147 men and 249 women) middle-aged, baseline apparently healthy, normotensive subjects participating in a 6.5-year follow-up study. Subjects with high-sensitivity CRP (hs-  mg/L were excluded at the initial visit. At follow-up, the occurrence of HT was 32%. The levels of baseline IL-1 and IL-1ra were significantly higher for subjects who developed HT during the follow-up than for those who did not (IL-1 ; 0.67 0.62 pg/mL versus 0.56 0.32 pg/mL, and IL-1ra; 184 132 pg/mL versus 154 89 pg/mL, ). After adjustments for age, follow-up time, sex, baseline systolic BP, and BMI, our results confirm a statistically significant ( ) linear association between the quartiles of IL-1 and change of systolic BP during the study. After adjustments for age, follow-up time, sex, and BMI, our results also show a linear association between incident HT and the quartiles of IL-1ra. ( ). These results provide evidence that proinflammation may precede BP elevation and HT.