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Mediators of Inflammation
Volume 2008, Article ID 631414, 5 pages
Research Article

Comparison of C-Reactive Protein and Serum Amyloid A Protein in Septic Shock Patients

Divisão de Anestesia, Departamento de Cirurgia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, 01246-903 São Paulo, SP, Brazil

Received 20 September 2007; Revised 14 November 2007; Accepted 2 January 2008

Academic Editor: Freek Zijlstra

Copyright © 2008 Domingos Dias Cicarelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Septic shock is a severe inflammatory state caused by an infectious agent. Our purpose was to investigate serum amyloid A (SAA) protein and C-reactive protein (CRP) as inflammatory markers of septic shock patients. Here we evaluate 29 patients in postoperative period, with septic shock, in a prospective study developed in a surgical intensive care unit. All eligible patients were monitored over a 7-day period by sequential organ failure assessment (SOFA) score, daily CRP, SAA, and lactate measurements. CRP and SAA strongly correlated up to the fifth day of observation but were not good predictors of mortality in septic shock.