Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine

Figure 2

NF-κB activity in the brain area surrounding the injury site in SHAM group (n = 5), TBI group (n = 6), and TBI-NAC group (n = 6). (Upper) EMSA autoradiography of NF-κB DNA binding activity. (Bottom) levels of NF-κB DNA binding activity quantified by computer-assisted densitometric scanning and expressed as arbitrary densitometric units (ADUs). As compared with SHAM group, NF-κB binding activity measured by EMSA was significantly increased in TBI group. Compared to TBI group, NAC significantly suppressed NF-κB activation in TBI-NAC group. ^∗∗𝑃<.01 versus SHAM group, ^##𝑃<.01 versus TBI group.