Disruption of Nrf2 Enhances Upregulation of Nuclear Factor-B Activity, Proinflammatory Cytokines, and Intercellular Adhesion Molecule-1 in the Brain after Traumatic Brain Injury
Figure 3
Concentrations of inflammatory cytokines in the cortex of sham and injured Nrf2 (+/+) and Nrf2
(−/−) mice. Concentrations of (a) TNF-α, (b) IL-1β, and (c) IL-6 were determined by
ELISA in the brain samples of Nrf2 (+/+) and Nrf2 (−/−) mice 24 hours
after TBI. The figure indicates that concentrations of TNF-α, IL-1β, and IL-6
in brain were significantly increased after TBI and were
greater in Nrf2 (−/−) mice than in Nrf2 (+/+) mice. Data
represents mean ± SEM ( per group). ** versus sham control of the
same genotype. # and ## versus
injured wild-type mice.
