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Mediators of Inflammation
Volume 2008, Article ID 834153, 6 pages
http://dx.doi.org/10.1155/2008/834153
Clinical Study

Platelet Counts and Platelet Activation Markers in Obese Subjects

1Department of Physiology and Pharmacology, School of Medicine, Sackler Faculty of Medicine, Tel-Aviv University, 69978 Ramat-Aviv, Israel
2Department of Internal Medicine D, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, 6 Weitzman Street, 64239 Tel-Aviv, Israel
3Obesity Center, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, 6 Weizman Street, 64239 Tel-Aviv, Israel
4Blood Bank and Transfusion Medicine, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel

Received 26 July 2007; Revised 18 November 2007; Accepted 31 January 2008

Academic Editor: Freek Zijlstra

Copyright © 2008 Dorit Samocha-Bonet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. In this work we studied the correlation between platelet count, platelet activation, and systemic inflammation in overweight, obese, and morbidly obese individuals. Methods and subjects. A total of 6319 individuals participated in the study. Complete blood counts, high sensitivity C-reactive protein (hs-CRP) serum levels, and body mass index (BMI) were measured during routine checkups. Platelet activation markers were studied among 30 obese (BMI = 41 ± 8 kg/m2) and 35 nonobese (BMI = 24 ± 3 kg/m2) individuals. Platelet activation status was evaluated by flow cytometry using specific antibodies against the activated platelet membrane glycoprotein IIb/IIIa, p-selectin (CD-62 p), and binding of Annexin-V to platelet anionic phospholipids. Results. Overweight, obese, and morbidly obese females had significantly elevated platelet counts ( 𝑃 < . 0 0 0 1 ) compared with normal-weight females. No significant elevation of platelet counts was observed in the male subgroups. A significant age adjusted correlation between BMI and platelet counts ( 𝑃 < . 0 0 0 1 ) was found among females. This correlation was attenuated ( 𝑃 = . 0 0 1 ) after adjustment for hs-CRP concentrations. The flow cytometry analysis of platelets showed no significant differences in activation marker expression between nonobese and obese individuals. Discussion. Obesity may be associated with elevated platelet counts in females with chronic inflammation. Obesity is not associated with increased platelet activation.