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Mediators of Inflammation
Volume 2009, Article ID 186136, 14 pages
http://dx.doi.org/10.1155/2009/186136
Research Article

Protection of Salvia miltiorrhizae to the Spleen and Thymus of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

1Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou 310006, Zhejiang Province, China
2Library, Hangzhou First People’s Hospital, Hangzhou 310006, Zhejiang Province, China
3The First College of Clinical Medicine, Zhejiang University of Traditional Chinese Medicine, Hangzhou 3100053, China
4Department of Nephropathy, 117 Hospital of People’s Liberation Army, Hangzhou 310013, Zhejiang Province, China

Received 12 May 2009; Accepted 31 August 2009

Academic Editor: TΓ’nia FrΓΆde

Copyright © 2009 Zhang Xiping et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To investigate the therapeutic effects and mechanism of Salvia miltiorrhizae in the treatment of SAP and OJ. Methods. A total of 288 rats were used for SAP- and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group and treated group. The mortality rates of rats, contents of endotoxin and P L A 2 in blood, patholodgical changes of different indexes in spleen and thymus were observed. Results. The contents of endotoxin and PLA2 in treated group were significantly lower than those in model control group.The pathological severity scores of spleen and thymus of SAP rats as well as that of spleen of OJ rats in treated groups were significantly lower than those in model control groups ( 𝑃 < . 0 5 ). The staining intensity as well as the product of the staining intensity and positive rate of Bax protein of spleen in model control group were significantly higher than those in treated groups ( 𝑃 < . 0 1 ) , and the apoptosis index of spleen in treated group was significantly lower than that in model control group ( 𝑃 < . 0 1 ). Conclusion. Salvia miltiorrhizae exerts protective effects on the spleen and thymus of SAP rats and spleen of OJ rats.