Correlation of Plasma MMP-1 and TIMP-1 Levels and the Colonic Mucosa Expressions in Patients with Ulcerative Colitis

Table 1

MMP-1 levels in colonic mucosa and plasma.

	Controls	UC	Mild	Moderate-to-severe
	(𝑛=12)	(𝑛=30)	(𝑛=12)	(𝑛=18)
Colonic mucosa
RT-PCR
MMP-1	0.27 ± 0.04	0.63 ± 0.23^∗	0.46 ± 0.08^∗	0.80 ± 0.19^∗̂‌
TIMP-1	0.51 ± 0.08	0.92 ± 0.24^∗	0.75 ± 0.14^∗	1.06 ± 0.22^∗̂‌
Immunohistochemistry
MMP-1	0.005 ± 0.001		0.075 ± 0.003^∗	0.081 ± 0.003^∗̂‌
TIMP-1	0.013 ± 0.003		0.080 ± 0.003^∗	0.090 ± 0.006^∗̂‌
Plasma
ELISA
MMP-1	1.90 ± 0.37	2.46 ± 0.60^∗	2.21 ± 0.40	2.68 ± 0.68
TIMP-1	5.59 ± 0.30	6.37 ± 0.54^∗	6.14 ± 0.48^∗	6.60 ± 0.50^∗̂‌

^∗𝑃<.05 compared to controls𝑃̂<.05 compared to 𝑀 group