IL-1β Suppresses the Formation of Osteoclasts by Increasing OPG Production via an Autocrine Mechanism Involving Celecoxib-Related Prostaglandins in Chondrocytes
Figure 2
Effect of IL-1β on M-CSF gene and protein expression. (a) Cells were cultured with 0, 10, or 100 U/mL IL-1β and M-CSF gene expression was determined by real-time PCR on days 1, 3, 5, 7, 10, 14, 21, and 28 of culture. (b) M-CSF protein expression determined by ELISA on days 21 and 28. Each bar indicates the mean ± SD from four separate experiments. , for IL-1β treatment versus the control.
