IL-1β Suppresses the Formation of Osteoclasts by Increasing OPG Production via an Autocrine Mechanism Involving Celecoxib-Related Prostaglandins in Chondrocytes
Figure 4
Effect of IL-1β and/or celecoxib on RANKL, M-CSF, and OPG gene expression. Cells were cultured with 0 or 100 U/mL IL-1β, with or without 1 M celecoxib, and RANKL, M-CSF, and OPG gene expression was determined by real-time PCR on days 21 and 28 of culture. Each bar indicates the mean SD from four separate experiments. , for IL-1β treatment versus the control.
