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Mediators of Inflammation
Volume 2009, Article ID 390951, 6 pages
http://dx.doi.org/10.1155/2009/390951
Clinical Study

Association of MCP-1 -2518 A/G Single Nucleotide Polymorphism with the Serum Level of CRP in Slovak Patients with Ischemic Heart Disease, Angina Pectoris, and Hypertension

1Institute of Immunology, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia
2Department of Internal Medicine II, Faculty of Medicine, Comenius University, 813 69 Bratislava, Slovakia
3Department of Internal Medicine I, Faculty of Medicine, Comenius University, 813 69 Bratislava, Slovakia
4Laboratory of Immunogenomics, Department of Immunology, Faculty of Medicine, Palacky University, 77 900 Olomouc, Czech Republic
5Department of Internal Medicine I, Faculty Hospital, 77 900 Olomouc, Czech Republic
6Institute of Pathological Physiology, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia

Received 29 May 2009; Accepted 29 May 2009

Academic Editor: Sunit Kumar Singh

Copyright © 2009 Maria Bucova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) and in control group of healthy subjects. Totally, 263 patients with the diagnosis of IHD, out of them 89 with MI, 145 with AP, 205 with HT, and also 67 healthy subjects were included in the study. First, we estimated the serum levels of hsCRP. We found that patients with AP had significantly higher serum level of hsCRP than both control group of healthy subjects ( ) and IHD patients without AP ( ). The presence of the mutant G allele statistically significantly correlated with the higher serum levels of hsCRP in patients with IHD ( ), AP ( ), and HT ( ). Higher correlations were found in men (AP: ; HT: ). In all cases the highest levels of hsCRP were found both in patients and healthy controls with homozygous GG genotype.