IL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group B Streptococcus Infection

Figure 2

Histopathological findings. Histophatolgical severity of arthritis was assessed in IL-4−/− mice or controls 10 days after infection. Arthritis was defined negative, mild moderate, or severe as detailed in Materials and Methods (see Section 2). Cumulative results of two independent experiments are represented. For each experimental group, 5 arthritic paws from IL-4−/− mice or control mice were removed, and 3 joints for each paw were assessed for histopathological score.