Influence of Melatonin on Cerebrovascular Proinflammatory Mediators Expression and Oxidative Stress Following Subarachnoid Hemorrhage in Rabbits
NF-B activity in the basilar arteries in control group (), SAH group (), SAH + vehicle group (), and SAH + melatonin group (). (a) EMSA autoradiography of NF-B DNA binding following SAH. (b) Levels of NF-B DNA binding activity quantified by computer-assisted densitometric scanning and expressed as an arbitrary densitometric units (ADUs). The activity of NF-B DNA binding was significantly increased in the animals of SAH and SAH + vehicle groups compared with the control group (). Compared to SAH or SAH + vehicle group, melatonin significantly suppressed NF-B activation in SAH + vehicle group (). Bars represent the mean SD. ** compared with control group, ns compared with SAH group; ## compared with SAH + vehicle group.
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