Mediators of Inflammation / 2009 / Article / Fig 2

Research Article

Influence of Melatonin on Cerebrovascular Proinflammatory Mediators Expression and Oxidative Stress Following Subarachnoid Hemorrhage in Rabbits

Figure 2

NF- B activity in the basilar arteries in control group ( ), SAH group ( ), SAH + vehicle group ( ), and SAH + melatonin group ( ). (a) EMSA autoradiography of NF- B DNA binding following SAH. (b) Levels of NF- B DNA binding activity quantified by computer-assisted densitometric scanning and expressed as an arbitrary densitometric units (ADUs). The activity of NF- B DNA binding was significantly increased in the animals of SAH and SAH + vehicle groups compared with the control group ( ). Compared to SAH or SAH + vehicle group, melatonin significantly suppressed NF- B activation in SAH + vehicle group ( ). Bars represent the mean SD. ** compared with control group, ns compared with SAH group; ## compared with SAH + vehicle group.

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