Mediators of Inflammation / 2009 / Article / Tab 4

Research Article

Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats

Table 4

Effects of sulfasalazine, doxantrazole, quercetine, and nedocromil treatment on damage score, changes in colonic weight, body weight, and incidence of diarrhea and adhesions in reactivated TNBS colitis.

Group ( )day 26thDamage score(a) (0–10)Colonic weight(b) (mg/cm)Body weight change (%)Adhesion (%)Diarrhoea (%)

Noncolitic 0*107.65 ± 6.80** 50.05 ± 2.45*0*0*
TNBS-control5(3–6) 145.56 ± 3.03 40.58 ± 1.155828.5
Sulfasalazine1(1–4) 142.52 ± 5.7745.02 ± 2.932014.0
Doxantrazole3(1–3) 132.50 ± 4.2240.45 ± 2.585828.5
Quercetin2(1–3) 138.08 ± 3.0044.49 ± 2.094014.0
Nedocromil1(1–3) 134.23 ± 5.8246.78 ± 1.984014.0

(a)Score data are expressed as median and interquartil interval. (b)Colonic weight data are expressed as mean S.E.M. *Groups differ significantly from the TNBS group . All groups differ significantly from the noncolitic (saline) group ( , not shown).

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