Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats

Table 4

Effects of sulfasalazine, doxantrazole, quercetine, and nedocromil treatment on damage score, changes in colonic weight, body weight, and incidence of diarrhea and adhesions in reactivated TNBS colitis.

Group (𝑛=5-7)day 26th	Damage score^(a) (0–10)	Colonic weight^(b) (mg/cm)	Body weight change (%)	Adhesion (%)	Diarrhoea (%)
Noncolitic	0*	107.65 ± 6.80^**	50.05 ± 2.45*	0*	0*
TNBS-control	5(3–6)	145.56 ± 3.03	40.58 ± 1.15	58	28.5
Sulfasalazine	1(1–4)	142.52 ± 5.77	45.02 ± 2.93	20	14.0
Doxantrazole	3(1–3)	132.50 ± 4.22	40.45 ± 2.58	58	28.5
Quercetin	2(1–3)	138.08 ± 3.00	44.49 ± 2.09	40	14.0
Nedocromil	1(1–3)	134.23 ± 5.82	46.78 ± 1.98	40	14.0

^(a)Score data are expressed as median and interquartil interval. ^(b)Colonic weight data are expressed as mean ± S.E.M. *Groups differ significantly from the TNBS group −𝑃<.05. All groups differ significantly from the noncolitic (saline) group (𝑃<.01, not shown).