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Mediators of Inflammation
Volume 2009 (2009), Article ID 439107, 4 pages
Clinical Study

Is Chronic Inflammation a Possible Cause of Obesity-Related Depression?

Department of Pathophysiology, Medical University of Silesia, 40-752 Katowice, Poland

Received 11 November 2008; Revised 17 March 2009; Accepted 27 May 2009

Academic Editor: Ariadne Malamitsi-Puchner

Copyright © 2009 Magdalena Olszanecka-Glinianowicz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Adult obesity has been associated with depression, especially in women. Whether depression leads to obesity or obesity causes depression is unclear. Chronic inflammation is observed in obesity and depression. In 63 obese women without additional diseases depression level was assessed with the Beck's questionnaire. After evaluation of depression level study group was divided into groups according to the mood status (A—without depression, B—mild depression, and C—severe depression), and serum concentration of TNF- , sTNFs, leptin, and IL-6 were measured by ELISA. No differences in age, body mass, BMI, and body composition were observed in study groups. We did not observe differences of serum concentrations of TNF- , sTNFRs, leptin, and IL-6 between subgroup A and subgroups B and C. It seems that circulating adipokines did not exert influence on depression levels in obese women.