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Mediators of Inflammation
Volume 2009 (2009), Article ID 510254, 7 pages
http://dx.doi.org/10.1155/2009/510254
Research Article

Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis

1Department of Cardiothoracic Surgery, Helsinki University Hospital, P.O. Box 340, 00029 Helsinki, Finland
2Department of Orthopedics and Traumatology, Tampere University Hospital, P.O. Box 2000, 33521 Tampere, Finland
3School of Medicine, Tampere University, 33104 Tampere, Finland
4Research Unit, Centre of Laboratory, Tampere University Hospital, P.O. BOX 2000, 33521 Tampere, Finland

Received 18 January 2009; Accepted 26 March 2009

Academic Editor: Oreste Gualillo

Copyright © 2009 Outi E. Päiväniemi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The local immunoreactivity of C-reactive protein (CRP) was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB). Bronchial allografts and control autografts were examined serially 2–28 days after subcutaneous transplantation. The autografts stayed patent. In the allografts, proliferation of inflammatory cells ( ) and fibroblasts ( ) resulted in occlusion of the bronchial lumens ( ). Influx of CD4+ ( ) and CD8+ ( ) cells demonstrated allograft immune response. CRP positivity simultaneously increased in the bronchial walls ( ), in macrophages, myofibroblasts, and endothelial cells. Local CRP was predictive of features characteristic of OB ( –0.879, .05− ). Early obliterative lesions also showed CRP positivity, but not mature, collagen-rich obliterative plugs ( ). During OB development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response.