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Mediators of Inflammation
Volume 2009, Article ID 512695, 6 pages
http://dx.doi.org/10.1155/2009/512695
Clinical Study

Serologic Investigations in Children with Inflammatory Bowel Disease and Food Allergy

1Gastroenterology Division, Department of Paediatrics, Medical University of Silesia, 40-752 Katowice, Poland
2Department of General, Molecular Biology and Genetics, Medical University of Silesia, 40-752 Katowice, Poland

Received 15 May 2009; Revised 27 August 2009; Accepted 8 November 2009

Academic Editor: Donna-Marie McCafferty

Copyright © 2009 Urszula Grzybowska-Chlebowczyk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of the study was the evaluation of frequency and titre of IgA ASCA and IgG ASCA and p-ANCA, c-ANCA in children with IBD and occurrence of ASCA antibodies in relation to coexistence of FA. Patients and methods. The study comprised 95 children at the ages of 2 to 18 years. The diagnosis of IBD was established on the basis of Porto criteria. Tests of blood serum were performed in all children: IgA and IgG ASCA, p-ANCA, c-ANCA using ELISA method. Results. IgE-dependent FA was found in 32.5% children with UC and in 21% with CD. We did not observe any relation between the occurrence of FA and the frequency and ASCA titre. p-ANCA were significantly more frequent in the group of children with UC. The occurrence of ASCA antibodies was observed in 73.7% of children with CD, 17.5% with UC and almost 30% with allergic colitis. Conclusions. Patients with CD and the presence of ASCA revealed a significantly more frequent localization of lesions within the small bowel and a tendency towards older age. We observed a connection between the occurrence of antibodies and the examined mutations of gene NOD2/CARD15.