Mediators of Inflammation

Research Article

High Levels of Proinflammatory Cytokines, but Not Markers of Tissue Injury, in Unaffected Intestinal Areas from Patients with IBD

Table 1

Clinical information from IBD patients included in the study according to the Montreal classification [13]. Age groups: A2 17–40 years, and A3 > 40 years. UC affected area: E1 proctitis, E2 left colitis or rectosigmoditis (E2-RS), and E3 pancolitis. UC grade: S1 mild colitis, S2 moderate colitis, and S3 severe colitis. CD affected area: L1 terminal ileon, L2 colon, L3 ileocolonic, and “p” periananal affectation. CD presentation: B1 nonstricturing and nonpenetrating (formerly known as inflammatory), B2 stricturing, and B3 penetrating.


Ulcerative colitis

Case No.	Age group	Sex	Biopsy availability (affected/unnafected areas)	UC grade	Affected area	Treatment

UC-1	A3	M	Both	S1	E2-RS	5-ASA
UC-2	A2	M	Both	S3	E2-RS	None
UC-3	A2	M	Both	S3	E2	None
UC-4	A3	M	Both	S1	E2	5-ASA
UC-5	A3	M	Both	S3	E2	None
UC-6	A3	M	Both	S2	E1	None
UC-7	A2	F	Both	S3	E2	None
UC-8	A3	M	Both	S3	E1	5-ASA
UC-9	A2	M	Both	S2	E1	None
UC-10	A3	M	Both	S1	E1	5-ASA
UC-11	A2	M	Both	S2	E3	Methylprednisone
UC-12	A3	M	Both	S3	E2	None
UC-13	A2	M	Both	S2	E1	5-ASA
UC-14	A2	M	Both	S1	E2-RS	None
UC-15	A3	M	Both	S2	E2	Methylprednisone
UC-16	A3	F	Both	S3	E1	5-ASA
UC-17	A2	M	Both	S3	E1	5-ASA
UC-18	A3	M	Both	S3	E3	5-ASA
UC-19	A2	M	Both	S2	E2	5-ASA
UC-20	A2	F	Both	S3	E1	None
UC-21	A3	M	Both	S3	E2	5-ASA
UC-22	A3	F	Both	S1	E2-RS	None
UC-23	A2	F	Affec. only	S3	E3	5-ASA
UC-24	A2	F	Affec. only	S2	E2	5-ASA
UC-25	A3	M	Affec. only	S2	E2	5-ASA
UC-26	A3	M	Affec. only	S2	E1	5-ASA

Crohn’s disease

Case No.	Age group	Sex	Biopsy availability (affected/unnafected areas)	CD presentation	Affected area	Surgery	Treatment

CD-1	A2	M	Both	B1	L1	No	None
CD-2	A3	F	Both	B2	L1	No	None
CD-3	A3	M	Both	B3	L2	Yes	Budesonide
CD-4	A2	F	Both	B1p	L1	Yes	Topic steroids + 5-ASA
CD-5	A2	M	Both	B1	L1	No	Oral steroids
CD-6	A2	M	Both	B1	L2	No	5-ASA
CD-7	A2	M	Both	B3	L3	Yes	Budesonide +5-ASA
CD-8	A3	F	Both	B1p	L1	Yes	Topic steroids + 5-ASA
CD-9	A2	F	Both	B2	L1	No	None
CD-10	A2	F	Both	B1	L1	No	5-ASA
CD-11	A2	F	Both	B1	L1	No	5-ASA
CD-12	A3	M	Both	B3	L1	No	5-ASA
CD-13	A2	F	Both	B1	L1	No	5-ASA
CD-14	A2	F	Both	B1	L1	No	None
CD-15	A2	M	Both	B1p	L3	Yes	Topic 5-ASA
CD-16	A3	M	Affec. only	B1	L1	No	5-ASA