Monocyte Chemoattractant Protein 1 is a Prognostic Marker in ANCA-Associated Small Vessel Vasculitis

Table 3

Statistical plausibility of raised potential markers to be associated with outcome and relapse respectively. Severe outcome defined as critical damage, according to (vasculitis damage index VDI) and death. U = urine, MCP-1 = monocyte chemoattractant protein 1, IgM = immunoglobulin M, IL-6 = interleukin 6, IL-8 = interleukin 8, P = plasma, ANCA = antineutrophil cytoplasmatic autoantibodies, CRP = C-reactive protein, BVAS = Birmingham vasculitis activity score. For statistics, the Man Whitney U-test and Kruskall-Wallis’ test were employed.

	Severe outcome	Relapse within 3 months
U-MCP-1	𝐏<.𝟎𝟎𝟏	𝑃=.08
U-IgM	𝑃=.07	𝑃=.39
U-IL-6	𝑃=.10	𝐏=.𝟎𝟒
U-IL-8	𝐏=.𝟎𝟓	𝑃=.2
P-IL-6	𝑃=.45	𝐏<.𝟎𝟎𝟏
P-IL-8	𝑃=.09	𝑃=.2
ANCA	𝑃=.48	𝑃=.09
CRP	𝑃=.23	𝑃=.68
Creatinine	𝐏<.𝟎𝟎𝟏	𝑃=.32
Cystatin C	𝐏<.𝟎𝟎𝟏	𝑃=0.6
BVAS	𝑃=.63	𝑃=0.18