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Mediators of Inflammation
Volume 2009, Article ID 675195, 7 pages
Research Article

Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

1Department of General Surgery, Hangzhou First People’s Hospital, Zhejiang Province, Hangzhou 310006, China
2The First College of Clinical Medicine, Zhejiang Traditional Chinese Medicine University, Zhejiang Province, Hangzhou 310053, China

Received 24 October 2009; Accepted 21 December 2009

Academic Editor: Vera L. Petricevich

Copyright © 2009 Zhang Xiping et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To observe the effect of salvia miltiorrhizae injection on inflammatory mediator levels and mesenteric lymph nodes in severe acute pancreatitis (SAP) and obstructive jaundice (OJ) rats and explore the protective mechanism of salvia miltiorrhizae on the lymph nodes of these rats. Methods. A total of 288 rats were used in SAP-associated and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group, and treated group. At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively. Results. The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group ( ) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation. Conclusion. Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood.