The Discovery of Novel Experimental Therapies for Inflammatory Arthritis

Figure 3

Activation of MEK 1/2 and ERK 1/2 by MAP3K. The phosphorylation (i.e., activation) of A-Raf, B-Raf or c-RAF, by MAPKKK (i.e., MAP3K) results in MAP2K-mediated phosphorylation of MEK 1/2 and downstream activation of ERK 1/2 (reviewed in [27]).