The Discovery of Novel Experimental Therapies for Inflammatory Arthritis

Table 1

Some novel experimental therapies alter the severity of arthritis in animal models.

Target	Drug	Animal Model	Results	Reference
Spleen Tyrosine Kinase	R788/R406	Murine CIA†	↓ Arthritis	[68]
			↓ Cytokines
MEK	PD184352	Murine CIA	↓ Arthritis	[82]
			↓ Proteoglycan degradation
ERK	FR180294	Murine CIA	↓ T cell activation	[83]
miR-15a	miR-15a	Murine Autoantibody‡	↑ Apoptosis	[85]
			↓ bcl-2
			↑ caspase-3
TRAIL	rhTRAIL*	Rabbit IL-1𝛽-transfected fibroblasts∗∗	↑ Apoptosis	[86]
			↓ Lymphocyte infiltration
Proteasome	Bortezomib	Murine CIA	↓ Arthritis	[87]
			↓ TNF-𝛼,IL-1𝛽, IL-6,iNOS, COX-2
			↓ MMP-3

† Type II Collagen-Induced Arthritis
‡ FAM-atelocollagen + miR-15a
∗ Recombinant human TRAIL
∗∗ IL-1𝛽-transfected human fibroblasts engrafted into rabbit synovial joint.