Oxymatrine Downregulates TLR4, TLR2, MyD88, and NF-B and Protects Rat Brains against Focal Ischemia
Figure 4
RT-PCR results of TLR2 and MyD88. (a) RT-PCR of TLR2 at 24 hours after the operation in each group: expression of TLR2 mRNA was evidently higher in the saline group compared with that in the OMT treatment group, and the difference was significant (). (b) RT-PCR of MyD88 at 48 hours after the operation in each group: expression of MyD88 mRNA was similar to that of TLR2 mRNA. (c) RT-PCR of TLR2 at all time points: expression of TLR2 mRNA was evidently higher in the saline group at 6 hours and lasted up to 48 hours. There was no difference between saline and OMT group at 6 hours. Compared with the saline group at 24 hours and 48 hours, expression of TLR2 mRNA was lower in the OMT treatment group, and the difference was significant compared with Sham and compared with saline group. (d) RT-PCR of MyD88 at all time points: expression of mRNA was similar to that of TLR2 mRNA. compared with Sham and compared with saline group.
