Oxymatrine Downregulates TLR4, TLR2, MyD88, and NF-B and Protects Rat Brains against Focal Ischemia
Figure 5
TLR4 expression detected by immunohistochemistry. (a) TLR4 expression in the sham group: TLR4 expression could not be observed in the sham group at 24 hours. (b) TLR4 expression in the saline group: TLR4 expression evidently increased in the saline group at 24 hours. Positive cells were defined as having buffy grains in the cytoplasm. (c) TLR4 expression in the OMT treatment group: TLR4 expression decreased relatively in the OMT treatment group at 24 hours. (d) TLR4 expression in each group at all time points: TLR4 expression showed no difference among all the test groups at 6 hours. It was evidently higher in the saline group at 24 hours and lasted up to 48 hours. Compared with the saline group at identical time points, TLR4 expression was lower in the OMT treatment group, and the difference was significant and compared with Sham.
