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Mediators of Inflammation
Volume 2009, Article ID 729172, 9 pages
http://dx.doi.org/10.1155/2009/729172
Review Article

Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel Diseases

Department of Gastroenterology, Ghent University, De Pintelaan 185, 9000 Gent, Belgium

Received 26 January 2009; Accepted 3 July 2009

Academic Editor: Donna-Marie McCafferty

Copyright © 2009 Anouk Waeytens et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [28 citations]

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  • Shuzo Ohata, Chihiro Moriyama, Atsushi Yamashita, Tadashi Nishida, Chiaki Kusumoto, Shinsuke Mochida, Yukari Minami, Junya Nakada, Kohei Shomori, Yoshimi Inagaki, Yoshiji Ohta, and Tatsuya Matsura, “Polaprezinc protects mice against endotoxin shock,” Journal of Clinical Biochemistry and Nutrition, vol. 46, no. 3, pp. 234–243, 2010. View at PublisherView at Google Scholar
  • Lena J. John, Michael Fromm, and Joerg-Dieter Schulzke, “Epithelial Barriers in Intestinal Inflammation,” Antioxidants & Redox Signaling, vol. 15, no. 5, pp. 1255–1270, 2011. View at PublisherView at Google Scholar
  • Hala E. Hamouda, Soha S. Zakaria, Saber A. Ismail, Mahmoud A. Khedr, and Wael W. Mayah, “p53 antibodies, metallothioneins, and oxidative stress markers in chronic ulcerative colitis with dysplasia,” World Journal Of Gastroenterology, vol. 17, no. 19, pp. 2417–2423, 2011. View at PublisherView at Google Scholar
  • Lindsey Devisscher, Pieter Hindryckx, Kim Olievier, Harald Peeters, Martine De Vos, and Debby Laukens, “Inverse correlation between metallothioneins and hypoxia-inducible factor 1 alpha in colonocytes and experimental colitis,” Biochemical and Biophysical Research Communications, vol. 416, no. 3-4, pp. 307–312, 2011. View at PublisherView at Google Scholar
  • Palma Simoniello, Chiara Maria Motta, Rosaria Scudiero, Francesca Trinchella, and Silvana Filosa, “Cadmium-induced teratogenicity in lizard embryos: Correlation with metallothionein gene expression,” Comparative Biochemistry And Physiology C-Toxicology & Pharmacology, vol. 153, no. 1, pp. 119–127, 2011. View at PublisherView at Google Scholar
  • Parimal Talukder, Tomomitsu Satho, Keiichi Irie, Tanjina Sharmin, Dieng Hamady, Yukihiko Nakashima, Nobuhiro Kashige, and Fumio Miake, “Trace metal zinc stimulates secretion of antimicrobial peptide LL-37 from Caco-2 cells through ERK and p38 MAP kinase,” International Immunopharmacology, vol. 11, no. 1, pp. 141–144, 2011. View at PublisherView at Google Scholar
  • Shinya Yamada, Yuji Naito, Tomohisa Takagi, Katsura Mizushima, Ryusuke Horie, Kohei Fukumoto, Ken Inoue, Akihito Harusato, Kazuhiko Uchiyama, Osamu Handa, Nobuaki Yagi, Hiroshi Ichikawa, and Toshikazu Yoshikawa, “Rebamipide ameliorates indomethacin-induced small intestinal injury in rats via the inhibition of matrix metalloproteinases activity,” Journal of Gastroenterology and Hepatology, vol. 27, no. 12, pp. 1816–1824, 2012. View at PublisherView at Google Scholar
  • Linda Gillberg, Mark Varsanyi, Mattias Sjöström, Mikael Lördal, Johan Lindholm, and Per M Hellström, “Nitric oxide pathway-related gene alterations in inflammatory bowel disease,” Scandinavian Journal of Gastroenterology, vol. 47, no. 11, pp. 1283–1298, 2012. View at PublisherView at Google Scholar
  • Angharad R. Morgan, Alan G. Fraser, and Lynnette R. Ferguson, “Metallothionein genes: No association with Crohn's disease in a New Zealand population,” Journal of Negative Results in BioMedicine, vol. 11, no. 1, 2012. View at PublisherView at Google Scholar
  • Jerome Breton, Catherine Daniel, Stephanie Pothion, Mathieu Sauty, Benoit Foligne, Bruno Pot, Patrick Thomas, Joelle Dewulf, and Nathalie Froux, “Gut microbiota limits heavy metals burden caused by chronic oral exposure,” Toxicology Letters, vol. 222, no. 2, pp. 132–138, 2013. View at PublisherView at Google Scholar
  • Michael A. Lynes, Juan Hidalgo, Yasmina Manso, Lindsey Devisscher, Debby Laukens, and David A. Lawrence, “Metallothionein and stress combine to affect multiple organ systems,” Cell Stress and Chaperones, 2014. View at PublisherView at Google Scholar
  • Kelly S. Hayes, and Richard K. Grencis, “Sex-dependent genetic effects on immune responses to a parasitic nematode,” Bmc Genomics, vol. 15, 2014. View at PublisherView at Google Scholar
  • Lindsey Devisscher, Pieter Hindryckx, Michael A Lynes, Anouk Waeytens, Claude Cuvelier, Filip De Vos, Christian Vanhove, Martine De Vos, and Debby Laukens, “Role of metallothioneins as danger signals in the pathogenesis of colitis,” The Journal of Pathology, 2014. View at PublisherView at Google Scholar
  • M. V. Sanz Fernandez, S. C. Pearce, N. K. Gabler, J. F. Patience, M. E. Wilson, M. T. Socha, J. L. Torrison, R. P. Rhoads, and L. H. Baumgard, “Effects of supplemental zinc amino acid complex on gut integrity in heat-stressed growing pigs,” Animal, vol. 8, no. 1, pp. 43–50, 2014. View at PublisherView at Google Scholar
  • Rebecca T. Emeny, Jane Kasten-Jolly, Tapan Mondal, Michael A. Lynes, and David A. Lawrence, “Metallothionein differentially affects the host response to Listeria infection both with and without an additional stress from cold-restraint,” Cell Stress and Chaperones, 2015. View at PublisherView at Google Scholar
  • Marina Ninkov, Aleksandra Popov Aleksandrov, Jelena Demenesku, Ivana Mirkov, Dina Mileusnic, Anja Petrovic, Ilijana Grigorov, Lidija Zolotarevski, Maja Tolinacki, Dragan Kataranovski, Ilija Brceski, and Milena Kataranovski, “Toxicity of oral cadmium intake: impact on gut immunity,” Toxicology Letters, 2015. View at PublisherView at Google Scholar
  • Mona A. El-Shahat, and Omnia S. Erfan, “The possible protective effect of metformin on acute experimental colitis induced by dextran sodium sulfate in mice: An immunohistochemical study,” Egyptian Journal of Histology, vol. 38, no. 3, pp. 594–604, 2015. View at PublisherView at Google Scholar
  • James M. Rice, Michael A. Lynes, and Adam Zweifach, “Metallothionein regulates intracellular zinc signaling during CD4+ T cell activation,” BMC Immunology, vol. 17, no. 1, 2016. View at PublisherView at Google Scholar
  • Sandra Pérez-Torras, Ingrid Iglesias, Marta Llopis, Juan J. Lozano, María Antolín, Francisco Guarner, and Marçal Pastor-Anglada, “Transportome Profiling Identifies Profound Alterations in Crohn’s Disease Partially Restored by Commensal Bacteria,” Journal of Crohn's and Colitis, vol. 10, no. 7, pp. 850–859, 2016. View at PublisherView at Google Scholar
  • Georg D. Duerr, Daniela Dewald, Eva J. Schmitz, Luise Verfuerth, Katharina Keppel, Christine Peigney, Alexander Ghanem, Armin Welz, and Oliver Dewald, “Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice,” Mediators of Inflammation, vol. 2016, pp. 1–13, 2016. View at PublisherView at Google Scholar
  • Alain Stintzi, Daniel Figeys, Zhibin Ning, Xu Zhang, Walid Mottawea, Ming Wen, Amanda E Starr, David R Mack, Shelley A Deeke, Cheng-Kang Chiang, Ruth Singleton, and Eric I Benchimol, “Proteomic analysis of ascending colon biopsies from a paediatric inflammatory bowel disease inception cohort identifies protein biomarkers that differentiate Crohn's disease from UC,” Gut, vol. 66, no. 9, pp. 1573–1583, 2017. View at PublisherView at Google Scholar
  • Mohammad Tariqur Rahman, and Muhammad Manjurul Karim, “Metallothionein: a Potential Link in the Regulation of Zinc in Nutritional Immunity,” Biological Trace Element Research, 2017. View at PublisherView at Google Scholar
  • Kavitha Subramanian Vignesh, and George Deepe Jr., “Metallothioneins: Emerging Modulators in Immunity and Infection,” International Journal of Molecular Sciences, vol. 18, no. 10, pp. 2197, 2017. View at PublisherView at Google Scholar
  • Iwona Mirończuk-Chodakowska, Anna Maria Witkowska, and Małgorzata Elżbieta Zujko, “Endogenous non-enzymatic antioxidants in the human body,” Advances in Medical Sciences, vol. 63, no. 1, pp. 68–78, 2018. View at PublisherView at Google Scholar
  • Thomas Greuter, Yannick Franc, Matthias Kaelin, Alain M. Schoepfer, Philipp Schreiner, Jonas Zeitz, Michael Scharl, Benjamin Misselwitz, Alex Straumann, Stephan R. Vavricka, Gerhard Rogler, Roland von Känel, and Luc Biedermann, “Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn’s disease patients,” Therapeutic Advances in Gastroenterology, vol. 11, pp. 1756283X1875771, 2018. View at PublisherView at Google Scholar
  • J.R.P.T. Castanheira, R.E.P. Castanho, H. Rocha, C. Pagliari, M.I.S. Duarte, A.L.S. Therezo, E.F.B. Chagas, and L.P.A. Martins, “Paradoxical effects of vitamin C in Chagas disease,” Parasitology International, vol. 67, no. 5, pp. 547–555, 2018. View at PublisherView at Google Scholar
  • Rune R. Tronstad, Tatiana Polushina, Hans-Richard Brattbakk, Christine Stansberg, Hilde Løland von Volkmann, Kurt Hanevik, Eva Ellinghaus, Silje Fjellgård Jørgensen, Kari Merete Ersland, Khanh D.-C. Pham, Odd Helge Gilja, Nils Hovdenak, Trygve Hausken, Morten H. Vatn, Andre Franke, Per Morten Knappskog, Stephanie Le Hellard, Tom Hemming Karlsen, and Torunn Fiskerstrand, “ Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C -linked familial diarrhea ,” Scandinavian Journal of Gastroenterology, pp. 1–10, 2018. View at PublisherView at Google Scholar
  • Kristen E. Dostie, Amy V. Thees, and Michael A. Lynes, “Metallothionein: A novel therapeutic target for treatment of inflammatory bowel disease,” Current Pharmaceutical Design, vol. 24, no. 27, pp. 3155–3161, 2018. View at PublisherView at Google Scholar