Influence of Epinastine Hydrochloride, an -Receptor Antagonist, on the Function of Mite Allergen-Pulsed Murine Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo
Figure 1
Influence of epinastine
hydrochloride (EP) on immunomodulatory cytokine production from dendritic cells
(DCs) stimulated with Dermatophagoides
farinae (Der f) in vitro. DCs derived from bone marrow
of BALB/c mice were stimulated with Der f in the presence of various concentrations of EP for 24 hours. IL-10 and IL12p40
levels in culture supernatants were examined by ELISA. The data are expressed
as the mean pg/mL ± SE of triplicate cultures. This is one of two different
experiments, which gave reproducible results.