Influence of Epinastine Hydrochloride, an -Receptor Antagonist, on the Function of Mite Allergen-Pulsed Murine Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo
Influence of epinastine
hydrochloride (EP) on immunomodulatory cytokine production from dendritic cells
(DCs) stimulated with Dermatophagoides
farinae (Der f) in vitro. DCs derived from bone marrow
of BALB/c mice were stimulated with Der f in the presence of various concentrations of EP for 24 hours. IL-10 and IL12p40
levels in culture supernatants were examined by ELISA. The data are expressed
as the mean pg/mL ± SE of triplicate cultures. This is one of two different
experiments, which gave reproducible results.
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