Influence of Epinastine Hydrochloride, an -Receptor Antagonist, on the Function of Mite Allergen-Pulsed Murine Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo
Figure 3
Influence of nasal
antigenic challenge on inflammatory cell appearance in nasal lavage fluid
obtained from mice instilled nasally with Dermatophagoides
farinae (Der f)-pulsed dendritic
cells. BALB/c mice were instilled nasally with Der f-pulsed and 25 ng/mL epinastine hydrochloride (EP)-treated DCs.
Nasal lavage was performed 24 hours after the final Der f allergen exposure. The data are expressed as the mean number
of cells ± SE of five mice. This is one of two different experiments, which
gave reproducible results. Der f alone: Der f allergen exposure alone; N.DC alone: nonpulsed DC instilled;
N.DC + Der f: nonpulsed DC instilled
and Der f allergen exposure; P. DC
alone: Der f-pulsed DC instilled; P.
DC + Der f: Der f-pulsed DC and Der f allergen exposure; P. DC + Der f +
EP: Der f-pulsed, EP-treated DC and Der f exposure.