Myeloperoxidase Content is a Marker of Systemic Inflammation in a Chronic Condition: The Example Given by the Periodontal Disease in Rats
Leukocyte number in blood collected from untreated control and treated periodontal-diseased rats.
Blood leukocytes (total cells/m; Mean SEM)
On the 11th day of tooth ligation, naive, drug-treated (celecoxib at 12 mg/kg/day and morphine at 1 mg/kg/day), and saline treated groups of animals were anesthetized with 23 mg/kg xylazine and 116 mg/kg ketamine hydrochloride, and blood samples were obtained by femoral vein bleeding. Whole blood cell counting (cells/m) was performed using a mixture of 20 L of blood samples + 380 L of Turk Blue in a Neubauer chamber under a light microscope (x 200-fold). Celecoxib and morphine were systemically administered for 3 consecutive days, from 3rd to 5th day after ligature placement as described in Materials and Methods. Statistical analysis: .05, one-way ANOVA followed by Student-Newman-Keuls test, 4–6 animals per group.
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