Circulating Cytokine Profiles and Their Relationships with Autoantibodies, Acute Phase Reactants, and Disease Activity in Patients with Rheumatoid Arthritis

Table 6

Correlations of RF, aMCV, and aCCP with cytokines, chemokines, and growth factors in the total cohort of RA patients (𝑛=140).

	RF	aMCV	aCCP
IL-1𝛽	0.5199	0.3823	0.3264
	0.0001	0.0061	0.0207
IL-1Ra	0.4193	0.4208	ns
	0.0024	0.0023
IL-2	0.4737	0.4399	0.3607
	0.0005	0.0014	0.0101
IL-4	0.6718	0.5277	0.5096
	0.0000	0.0001	0.0002
IL-6	0.3970	0.4693	0.4346
	0.0043	0.0006	0.0016
IL-7	0.5021	0.3244	0.3665
	0.0002	0.0215	0.0088
IL-8	0.3407	ns	ns
	0.0155
IL-10	0.4339	0.4540	0.3450
	0.0016	0.0009	0.0142
IL-12	0.5732	0.4526	0.4396
	0.0000	0.0010	0.0014
IL-17A	0.2910	ns	ns
	0.0403
G-CSF	0.6254	0.5140	0.4969
	0.0000	0.0001	0.0002
GM-CSF	0.6150	0.5639	0.4552
	0.0000	0.0000	0.0009
IFN-γ	0.6561	0.5562	0.5473
	0.0000	0.0000	0.0000
TNF	0.5667	0.4920	0.4120
	0.0000	0.0003	0.0029
VEGF	0.4405	ns	ns
	0.0014
CCL2	0.3624	ns	ns
	0.0097
CCL4	0.3597	0.4444	0.3790
	0.0103	0.0012	0.0066

RF: Rheumatoid factor, aCCP: anticyclic citrullinated peptide antibodies, aMCV: Antimutated citrullinated vimentin antibodies.
ns: not significant.