Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study

Table 5

Association of lipoxygenase variants in ALOX5, ALOX5AP, and ALOX12 with mean levels of biomarker phenotypes.

Gene	SNP		ICAM-1	CRP	IL-6	E-selectin	Leptin	Adiponectin	MCP-1	MGP
ALOX5	rs2115819	TT	269.6	0.62	4.34	47.7	15.2	11.82	460.6	8.44
		TC	294.8	0.66	4.58	79.7	17.9	11.01	446.5	8.47
		CC	236.4	0.64	4.16	54.2	13.6	11.05	468.9	8.53
	rs3780906	GG	269.8	0.66	3.95	67.6	13.6	11.13	444.7	8.48
		GA	286.7	0.65	4.77	59.6	21.2	11.53	459.5	8.54
		AA	228.9	0.56	4.5	51.9	6.6	11.8	505.3	7.87
ALOX12	rs2271316	GG	295.7	0.43	3.14	58.4	25.5	12.33	439.4	8.5
	(17947)	GC	268.3	0.75	4.68	59.3	15.7	11.03	465.3	8.59
		CC	266	0.56	4.31	67.3	13.4	11.01	429.8	8.09
ALOX5AP	rs10507391	AA	272.6	0.67	4.96	57.6	20.5	11.46	450.8	7.87
	(4431)	AT	262.2	0.6	3.9	63.8	13	11.77	459.3	8.62
		TT	290.1	0.7	4.82	77.1	15.7	9.52	459	9.83
	rs9506352	GG	273.2	0.69	4.3	68.7	12.9	10.69	451.7	9.06
	(13151)	GA	267.4	0.55	4.32	59.8	15.4	11.93	457	8.08
		AA	281	0.76	4.22	58.8	26	12.35	472.3	7.64
	rs4769060	AA	290.6	0.71	4.76	70.2	12.6	9.88	466.7	8.89
	(30231)	AG	260.9	0.57	4.23	61.1	14.6	12.1	450.9	8.41
		GG	278.1	0.74	4.4	63.2	22.6	11.75	443.7	7.88