Research Article
Metabolic Phenotype and Adipose Tissue Inflammation in Patients with Chronic Obstructive Pulmonary Disease
Table 4
Adipose tissue-relative expressions of interleukin 6, tumor necrosis factor-alpha and its receptor, CD68, CASP3, and Bax gene in patients with COPD.
| | mRNA expression (ΔΔCt) | Entire group | Group | P value | | Cachectic | Normal weight | Overweight | Obese |
| | IL-6 | 3.1 (1.3–4.3) | 0.9 (0.5–1.0) | 2.4 (1.4–4.7) | 3.8 (2.9–4.8)* | 3.9 (3.1–4.9)* | <.001 | | TNF-α | 5.5 (4.2–7.1) | 5.1 (3.4–6.0) | 4.6 (3.3–6.0) | 5.5 (5.2–6.4) | 9.6 (6.1–10.2)*†‡ | .005 | | TNFRSF1A | 9.7 (8.0–11.8) | 8.1 (6.4–9.5) | 9.7 (8.2–11.9) | 9.8 (8.1–11.7) | 11.3 (9.7–15.3) | .011 | | CD68 | 9.9 (7.9–16.7) | 5.3 (4.6–8.1) | 9.5 (6.7–11.0) | 11.7 (9.3–17.2)* | 18.0 (11.2–23.5)*† | .011 | | CASP3 | 5.3 (4.7–6.7) | 5.3 (4.9–6.0) | 4.7 (3.9–7.8) | 5.0 (4.4–6.9) | 6.2 (5.7–6.7) | .890 | | Bax | 2.2 (0.4–8.6) | 0.9 (0.3–2.8) | 3.3 (0.6–10.1) | 1.4 (0.4–4.6) | 6.5 (0.3–9.5) | .175 | | Adipocyte diameter (μm) | 68.2 (59.0–77.0) | 48.1 (37.7–63.0) | 60.6 (57.7–65.2) | 69.7 (65.9–78.7)* | 77.0 (75.3–77.9)*† | <.001 |
|
|
*
versus cachectic group.
† versus normal-weight group.
‡ versus overweight group.
Values are given as median (interquartile range).
Relative mRNA expression was calculated using comparative quantification method (ΔΔCt).
IL-6: interleukin 6; TNF-α: tumor necrosis factor alpha; TNFRSF1A: tumor necrosis factor superfamily receptor 1A; CASP3: Caspase 3.
|
