Mediators of Inflammation

Research Article

Metabolic Phenotype and Adipose Tissue Inflammation in Patients with Chronic Obstructive Pulmonary Disease

Table 5

Linear relationships between IL-6, TNF-α, and CD68 relative expressions in adipose tissue and insulin sensitivity, BMI, adipocyte diameter, FEV₁, arterial oxygen saturation, and serum inflammatory markers.


	IL-6 (Log ΔΔCt)		TNF-α (Log ΔΔCt)		CD68 (Log ΔΔCt)
	R value	P value	R value	P value	R value	P value

M/I, mg·kg^-1·min^-1·μU^-1·mL	−0.716	<.001	−0.438	.003	−0.425	.004
BMI, kg·m^-2	0.565	<.001	0.448	.003	0.445	.003
Adipocyte diameter, μm	0.593	<.001	0.347	.024	0.469	.002
FEV₁, % pred	0.245	.108	0.055	.727	0.014	.929
PaO₂, mm Hg	0.224	.145	0.023	.882	0.015	.924
CASP3 mRNA expression, (ΔΔCt)	0.249	.107	0.172	.259	0.023	.902
Bax mRNA expression, (ΔΔCt)	0.232	.142	0.094	.560	0.120	.454
Serum TNF-α (Log pg·mL^-1)	−0.234	.131	−0.013	.934	0.178	.253
Serum IL-6 (Log pg·mL^-1)	0.232	.139	0.271	.083	0.364	.018
hsCRP (Log mg·L^-1#)	0.180	.247	0.220	.157	0.212	.171

PaO₂: arterial oxygen partial pressure; M/I: insulin sensitivity—glucose uptake to insulinemia ratio; BMI: body mass index; FEV₁: forced expiratory volume in 1 second; CASP3: caspase 3; TNF-α: tumor necrosis factor alpha; IL-6: interleukin-6; hsCRP: high sensitivity C-reactive protein.