Rhizoma coptidis Inhibits LPS-Induced MCP-1/CCL2 Production in Murine Macrophages via an AP-1 and NF𝜅B-Dependent Pathway

Figure 3

Gel-shift analysis of the transcripton factor NF$\kappa$ B. Treatment with Rhizoma coptidis inhibited binding activity in a dose-dependent (incubation time 240 min), (a) and time-dependent (dilution $1:5$), (b) fashion. NF$\kappa$ B: nuclear factor$\kappa$ B, Co: LPS-stimulated control cells, and CC: cold competition. ${}^{*}P<.005\text{,}$${}^{**}P<.001$.

(a)

(b)