Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes

Figure 3

Cells and receptors involved in AA metabolism in the innate immune system. PMN respond to cooperative binding of dectin-1 and CR3, to the cross-linking of Fc$\gamma$R, to mannose-based PAMP, and to G-protein-coupled receptors (GPCR) in the presence of priming agents. The receptor involved in the response to PGN has not been characterized as yet. Macrophages express a similar array of receptors showing productive binding. In DC the most efficient response is obtained by triggering dectin-1 and DC-SIGN by PAMP containing $\beta$-glucan and mannose polymers, respectively.