Examining the Genomic Influence of Skin Antioxidants In Vitro

Table 5

Summary of keratinocyte genes noted to be commonly upregulated by the antioxidant treatments.

KERATINOCYTES	Test Materials	Pomiferin	Osajtn	Resveratrol	EGCG	Genistein	Rosavin	Puerarin	Chlorogenic Acid	Propolis
Gene Name	Gene Description
ACLY	ATP citrate lyase	3.499	1.769	1.46	1.047	0.887	1.319	1.461	0.981	1.541
AQP1	Aquaporin 1	3.288	2.098	1.575	0.436	0.947	1.34	1.757	2	1.736
AQP3	Aquaporin 3	1.65	1.055	1.598	1.636	2.587	1.17	1.418	1.319	1.451
CD44	Transmembrane glycoprotein CD44	2.312	1.345	1.236	0.867	1.504	0.758	1.07	1.34	1.398
CDH1	Cadherin 1	2.489	1.489	1.599	0.989	1.152	0.934	1.379	1.582	1.422
COX1	Cytochrome c oxidase 1	2.637	2.045	1.421	0.985	0.914	1.354	1.217	2.499	2.149
FGFl	Fibroblast growth factor 1	2.65	1.67	1.519	0.194	0.316	1.303	1.345	3	0.945
GRN	Granulin	2.976	1.652	1.496	0.959	0.936	1.281	1.297	1.452	1.57
HSPB1	Heat Shock 27 kD protein 1	2.991	1.437	1.539	1.028	0.922	1.406	1.42	2.581	1.768
KRT5	Keratin 5	2.964	2.197	1.704	1.008	0.573	1.258	1.134	2.439	2.141
NOS3	Nitric oxide synthase 3	3.152	1.859	1.609	0.981	0.893	1.277	1.311	1.041	1.812
PLOD3	Lysine hydroxylase 3	3.231	1.94	1.45	1.102	0.917	1.299	1.481	2.671	1.756
TPTl	Histamine-releasing factor	2.813	2.148	1.617	1.105	0.925	1.363	1.431	2.184	1.874
TXN	Thioredoxin	2.41	1.924	1.369	0.985	0.83	1.352	1.206	2.244	2.026