Examining the Genomic Influence of Skin Antioxidants In Vitro

Table 6

Summary of keratinocyte genes noted to be commonly downregulated by the antioxidant treatments.

KERATINOCYTES	Test Materials	Pomiferin	Osajin	Resveratrol	EGCG	Genistein	Rosavin	Puerarin	Chlorogenic Acid	Propolis
Gene Name	Gene Description
AR	Androgen receptor	0.06	0.462	0.607	0.257	0.302	0.417	0.581	0	0.459
CYGB	Cytoglobin	0.175	0.414	0.636	0.319	0.242	0.268	0.571	0.688	0.667
EGF	Epidermal growth factor	0.159	0.52	0.741	0.25	0.204	0.272	0.516	0.471	0.774
ESR2	Estrogen receptor 2	0.093	0.444	0.706	0.192	0.727	0.26	0.478	0	0.438
FBN1	Fibrillin 1	0.52	0.78	0.75	0.215	0.214	0.337	0.667	0.563	0.612
FBN2	Fibrillin 2	0.731	0.917	0.857	0.32	0.473	0.541	0.693	0.571	0.634
IGF1	Insulin growth factor 1	0.135	0.588	0.6	0.31	0.429	0.381	0.5	0	0.462
KL	Klotho	0.038	0.273	0.545	0.357	0.278	0.181	0.444	0	0.4
MC1R	Melanocortin 1 receptor	0.167	0.571	0.619	0.302	0.433	0.19	0.561	2	0.538
PGR	Progestone receptor	0.052	0.538	0.8	0.304	0.217	0.293	0.235	2	0.5
POMC	Proopiomelanocortin	0.194	0.483	0.75	0.295	0.452	0.357	0.788	0.982	0.738
PPARG	Peroxisome proliferator activated receptor, gamma	0.154	0.563	0.571	0.314	0.129	0.538	0.45	0.333	0.438
PTGER1	Prostaglandin E receptor 1	0.107	0.6	0.667	0.209	0.235	0.245	0.657	1.25	0.629
RAD23A	RAD23 homolog A	0.391	0.482	1.034	0.385	0.414	0.578	0.971	0.577	0.789
RXRA	Retinoid X receptor, alpha		0.636		0.445	0.409	0.561		0.621	0.689
SOD3	Superoxide dismutase 3	0.13	0.571	0.467	0.276	0.431	0.617	0.6	0.571	0.778
SRD5A2	Steroid 5 alpha-reductase A2	0.097	0.556	0.636	0.371	0.333	0.588	0.529	0.5	0.583
TERT	Telomerase reverse transcriptase	0.311	0.595	0.619	0.298	0.394	0.436	0.556	0.709	0.756
TYRP1	Tyrosinase related peptide 1	0.043	0.852	0.611	0.34	0.244	0.296	0.7	0.5	0.5