Disruption of Nrf2 Enhances the Upregulation of Nuclear Factor-kappaB Activity, Tumor Necrosis Factor-𝛼, and Matrix Metalloproteinase-9 after Spinal Cord Injury in Mice

Figure 5

Protein expression levels of TNF-$\alpha$ in spinal cord samples of sham and injured Nrf2 (+/+) and Nrf2 (−/−) mice. The figure indicates that spinal cord contents of TNF-$\alpha$ were significantly increased and were higher in Nrf2 (−/−) mice than in Nrf2 (+/+) mice at 24 hours after SCI. Bars represent mean $\pm$ S.E. ($n=6$, each group). *$P<.01$ versus genotype-matched sham-operated mice. ^#$P<.05$ versus treatment-matched Nrf2 (+/+) mice.