Disruption of Nrf2 Enhances the Upregulation of Nuclear Factor-kappaB Activity, Tumor Necrosis Factor-𝛼, and Matrix Metalloproteinase-9 after Spinal Cord Injury in Mice

Figure 7

Gelatin zymography analysis for the activity of MMP-9 in spinal cord tissue of sham and injured Nrf2 (+/+) and Nrf2 (−/−) mice. (a) Representative gelatin images show the activity of MMP-9 in sham and injured Nrf2 (+/+) and Nrf2 (−/−) mice. (b) The graphs show that higher activity of MMP-9 was found in Nrf2 (−/−) mice than in Nrf2 (+/+) mice at 24 hours after SCI. Bars represent mean $\pm$ S.E. ($n=6$, each group). *$P<.01$ versus genotype-matched sham-operated mice. ^#$P<.01$ versus treatment-matched Nrf2 (+/+) mice.

(a)

(b)