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Mediators of Inflammation
Volume 2010, Article ID 263914, 5 pages
http://dx.doi.org/10.1155/2010/263914
Review Article

Inflammation, HIF-1, and the Epigenetics That Follows

Tumor Genetics Laboratory, National Institute for Cancer Research, Largo Benzi, 10, 16132 Genova, Italy

Received 4 August 2010; Revised 7 November 2010; Accepted 15 November 2010

Academic Editor: Changlin Li

Copyright © 2010 Claudio Brigati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We summarize recent findings linking inflammatory hypoxia to chromatin modifications, in particular to repressive histone signatures. We focus on the role of Hypoxia-Induced Factor-1 in promoting the activity of specific histone demethylases thus deeply modifying chromatin configuration. The consequences of these changes are depicted in terms of gene expression and cellular phenotypes. We finally integrate available data to introduce novel speculations on the relationship between inflammation, histones, and DNA function and integrity.