High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L.

Table 1

Body weights and non-fasting blood glucose concentrations in normal chow and high fat diet-fed mice maintained with and without PMI-5011 treatment.

Variable	Body weight, g		Blood glucose,  mmol l^−1
Group	Before T (16-wk time point)	After T (23-wk time point)	Before T (16-wk time point)	After T (23-wk time point)
NC	$37.5\pm 0.57$	$36.8\pm 0.74$	$7.50\pm 0.19$	$7.67\pm 0.25$
$\text{NC}+\text{T}$	$36.9\pm 0.80$	$36.3\pm 0.74$	$7.28\pm 0.18$	$7.82\pm 0.31$
HFD	$52.6\pm {0.36}^{**}$	$51.3\pm 0.57{}^{**}$	$8.58\pm 0.22{}^{**}$	$8.95\pm 0.50{}^{**}$
$\text{HFD}+\text{T}$	$53.7\pm {0.53}^{**}$	$50.8\pm 0.90{}^{**}$	$8.59\pm 0.19{}^{**}$	$7.82\pm {0.33}^{\S ,\#\#}$

Data are expressed as $\text{Mean}\pm \text{SEM}\text{,}$$n=10\text{–}33$ per group. NC: normal chow; T: treatment; HFD: high fat diet; ${}^{*,**}P<.05$ and $<.01$ versus mice fed NC; ${}^{\S }P<.05$ versus the baseline value (16-wk time point); ${}^{\#\#}P<.01$ versus untreated mice fed HFD (23-wk time point).