Effects of Brain-Derived Neurotrophic Factor on Local Inflammation in Experimental Stroke of Rat

<table>BDNF alleviated cellular injury of ischemic insult brain tissue sections obtained from injured cerebral hemispheres were stained with triphenyltetrazolium chloride (TTC) and TUNEL assay 24 h after reperfusion. (a) Infarct volume without any treatment. (b) Infarct volume with exogenous BDNF. (c) Infarct volume with exogenous BDNF antibody. (d) TUNEL assay in control group. (e) TUNEL assay in BDNF group. (f) TUNEL assay in antibody group. (g) No significant difference of infarct volume in the three groups. (h) Summary of TUNEL-positive cells 24 h after ischemia. Scar bar: 100 <i>μ</i>m. Bars represent mean ± SD (<svg height="9.8999996" id="M86" style="vertical-align:-0.1575pt" version="1.1" viewbox="0 0 31.475 9.8999996" width="31.475" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 11.21px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 11.21px; " x="8.6749916" y="0">=</tspan>
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<tspan style="font-size: 11.21px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 11.21px; " x="9.7621679" y="0">&lt;</tspan>
<tspan style="font-size: 11.21px; " x="20.555471" y="0">.</tspan>
<tspan style="font-size: 11.21px; " x="23.357471" y="0">0</tspan>
<tspan style="font-size: 11.21px; " x="28.961472" y="0">5</tspan>
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</svg> versus control group.</table>

Mediators of Inflammation

fig2

Figure 2

Figure 2: Effects of Brain-Derived Neurotrophic Factor on Local Inflammation in Experimental Stroke of Rat 