Effects of Brain-Derived Neurotrophic Factor on Local Inflammation in Experimental Stroke of Rat

Figure 3

BDNF increasing the number of activated microglia after stroke Activated microglia in brain was marked by OX-42 and detected by confocal microscope following immunofluorescence. (a–c) 6 h after reperfusion and (e–g) 24 h after reperfusion; (a, e) control group, (b, f) BDNF group and (c, g) antibody group. (h) The number of phagocytotic microglia in BDNF group was significantly increased than control group 6 h and 24 h after reperfusion. BDNF antibody significantly decreased the number of activated microglia 6 h after reperfusion. Bars represent mean ± SD (𝑛=6). ^∗𝑃<.05 versus control group, ^#𝑃<.05 versus BDNF group. Scale bars: 25 μm.

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