Effects of Brain-Derived Neurotrophic Factor on Local Inflammation in Experimental Stroke of Rat

<table>BDNF upregulating the number of phagocytotic microglia after stroke ED1 is well known as a marker of phagocytotic microglia. (a–c) 6 h after reperfusion and (d–f) 24 h after reperfusion; (a, d) control group, (b, e) BDNF group and (c, f) antibody group. BDNF significantly increased the number of phagocytotic microglia in brain 6 h and 24 h after reperfusion. The number of activated microglia was decreased in BDNF antibody group at 6 h of reperfusion. Bars represent mean ± SD (<svg height="9.8999996" id="M136" style="vertical-align:-0.1575pt" version="1.1" viewbox="0 0 31.475 9.8999996" width="31.475" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 11.21px; " x="0" y="0">𝑛</tspan>
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<tspan style="font-size: 7.85px; " x="0" y="0">∗</tspan>
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<tspan style="font-size: 11.21px; " x="0" y="0">𝑃</tspan>
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</svg> versus control group, <svg height="15.725" id="M138" style="vertical-align:-2.8125pt" version="1.1" viewbox="0 0 51.200001 15.725" width="51.200001" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 11.21px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 11.21px; " x="9.7700005" y="-0.85000002">&lt;</tspan>
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</svg> versus BDNF group. Scale bars: 25 <i>μ</i>m.</table>

Mediators of Inflammation

fig4

Figure 4

Figure 4: Effects of Brain-Derived Neurotrophic Factor on Local Inflammation in Experimental Stroke of Rat 