Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model
Table 1
The preventive versus curative effect of Celecoxib on bladder cancer: quantitative evaluation of urothelium lesions.
Macroscopy
Control
CEL
BBN
CEL+BBN-P
BBN+CEL-C
(quantitative)
()
()
()
()
()
Tumor number (%)
% of rats with tumor
0
0
(13 in 20) 65.0%
(1 in 8) 12.5%
(6 in 8) 75.0%
Nr tumors/rat with tumor
0
0
(16 in 13)
4.0† (4 in 1)
(11 in 6)
Tumor volume (mm3)
Mean/rat with tumor
0
0
(in 13)
21.2† (in 1)
(in 6)
Mean/tumor
0
0
(in 16)
(in 4)
(in 11)
†Represents only 1 rat in 8 of the group (s.e.m. in not applicable). Values are mean ± SEM, excepting for % of rats with tumor. BBN: N-butyl-N-(4-hydroxybutyl) nitrosamine; CEL: celecoxib; C: curative; P: preventive.