Research Article
Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model
Table 2
The preventive versus curative effect of Celecoxib on bladder cancer: qualitative evaluation of urothelium lesions.
| | Microscopy | Control | CEL | BBN () | CEL+BBN-P () | BBN+CEL-C () | | (qualitative) | () | () | Tumor group | Total group | Tumor group | Total group | Tumor group | Total group |
| | Preneoplasic lesions: %(nr/nr) | | | | | | | | | | Hyperplasia | 0 | 0 | 100 (13/13) | 100 (20/20) | 100 (1/1) | 37.5 (3/8) | 100 (6/6) | 100 (8/8) | | High-Grade Dysplasia | 0 | 0 | 100 (13/13) | 75 (15/20) | 0 (0/1) | 0 (0/8) | 14 (1/6) | 12.5 (1/8) | | Low-Grade Dysplasia | 0 | 0 | 0 (0/13) | 25 (5/20) | 100 (1/1) | 12.5 (1/8) | 83 (5/6) | 62.5 (5/8) |
| | Neoplasic lesions: %(nr/nr) | | | | | | | | | | Papillary tumor | 0 | 0 | 100 (13/13) | 65 (13/20) | 100 (1/1) | 12.5 (1/8) | 100 (6/6) | 75 (6/8) | | Infiltrative tumor | 0 | 0 | 15 (2/13) | 10 (2/20) | 0 (0/1) | 0 (0/8) | 0 (0/6) | 0 (0/8) | | Carcinoma In Situ | 0 | 0 | 31 (4/13) | 20 (4/20) | 0 (0/1) | 0 (0/8) | 0 (0/6) | 0 (0/8) |
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BBN: N-butyl-N-(4-hydroxybutyl) nitrosamine; CEL: celecoxib; C: curative; P: preventive.
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