Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats
Body mass (a) and food intake (b) in control rats on standard diet (CN ▲), high-fat diet (SHF ■), and food restriction (FR ♦), and in arthritic rats on standard diet (AA-N ∆), high-fat diet (AA-SHF □), and food restriction (AA-FR ◊) in selected days after cFA inoculation. Values for food intake are presented as means of 2 cages (4 rats per cage). Statistical significance between the body mass values in arthritic rats and their corresponding controls on the same dietary regime: . Significant difference between AA-N and AA-SHF: . First day of significant differences: CN versus SHF , FR versus CN , FR versus SHF , AA-FR versus AA-N , and AA-FR versus AA-SHF . Effects of dietary interventions on the severity of arthritis expressed by arthrogram score (c). Significant difference between AA-FR and AA-N: ; significant difference between AA-FR and AA-SHF: ; significant difference between AA-SHF and AA-N: .
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