The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors

Table 2

Cardiovascular risk markers and hepatic aminotransferases (Mean $\pm$ SEM) in GH-Deficient and GH-Sufficient Obese premenopausal women.

	GH Peak ($\le$3 ng/mL)	GH Peak ($>$3 ng/mL)	$P$ value
	$n=9$	$N=39$
Age (year)	$42.3\pm 2.3$	$30.4\pm 2.4$	NS
BMI (kg/${\text{m}}^2$)	$45.5\pm 1.6$	$33.8\pm 1.0$	$.007$
Mid-waist circumference (cm)	$117\pm 2.3$	$99.0\pm 3.1$	$.039$
Waist/hip ratio	$0.97\pm 0.04$	$0.89\pm 0.02$	NS
Total body fat ($\%$)	$46.9\pm 1.0$	$36.8\pm 1.2$	$.004$
Trunk fat (c${\text{m}}^2$)	$185.0\pm 6.7$	$131.2\pm 9.2$	$.048$
IGF-I (ng/mL)	$103.3\pm 6.5$	$158.3\pm 18.2$	NS
IGFBP-3	$4.9\pm 0.2$	$4.6\pm 0.3$	NS
Total cholesterol (mg/dL)	$231\pm 14.0$	$165\pm 8.3$	$.039$
HDL (mg/dL)	$43.5\pm 2.0$	$54.2\pm 1.8$	NS
LDL (mg/dL)	$173\pm 2.5$	$95.2\pm 7$	$.044$
Triglyceride (mg/dL)	$172\pm 29.5$	$86.4\pm 13.4$	$.047$
Fasting glucose (mg/dL)	$99.7\pm 2.0$	$91.7\pm 2.0$	NS
Fasting Insulin ($\mu$U/mL)	$20.9\pm 0.3$	$10.8\pm 1.3$	$.005$
HOMA-IR	$5.3\pm 0.25$	$2.6\pm 1.5$	$.018$
Leptin	$20.1\pm 3.5$	$24.7\pm 3.6$	NS
GOT (IU/L)	$31.3\pm 2.0$	$17.6\pm 1.0$	$.012$
GPT (IU/L)	$42.3\pm 4.4$	$20.2\pm 1.5$	$.022$
GGT (IU/L)	$65.0\pm 9.2$	$13.8\pm 1.2$	$.007$