Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis
Augmentation of ROS by various pathways under diabetic conditions. (a) ROS are produced by various pathways under diabetic conditions. Hyperglycemia induces ROS through activation of the glycation reaction and electron transport chain in mitochondria. (b) AGEs, insulin, and angiotensin II induces ROS through activation of membrane-bound NADPH oxidase.
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