Polymorphisms in Tumour Necrosis Factor Alpha (TNF𝛼) Gene in Patients with Acute Pancreatitis

Table 2

Genotype frequencies of TNFα among cases and controls and the association with AP risk. ORs with 95% CI and P-values were calculated for wild/wild genotype versus wild/mutant and mutant/mutant genotypes.

TNF$\alpha$ polymorphisms	Genotype	Cases (%) $n$ = 103	Controls (%) $n$ = 92	OR (95% CI)*	P-value
TNF$\alpha$^−308$\text{G}>\text{A}$ rs1800629	GG	15 (14.6)	21 (22.8)	GG versus any A	.145
	GA	43 (41.8)	34 (37.0)	1.63 (1.13−4.01)
	AA	45 (43.7)	37 (40.2)
TNF$\alpha$^−238$\text{G}>\text{A}$ rs361525	GG	90 (87.4)	73 (79.4)	GG versus any A	.175
	GA	8 (7.8)	18 (19.6)	0.86 (0.75−1.77)
	AA	5 (4.9)	1 (1.1)

${}_{}{}^{*}\text{OR}$: odds ratio; CI: 95% confidence interval; OR adjusted for age, sex, BMI, smoking status for logistic regression analysis.